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doi:10.1146/annurev.arplant.59.032607.092811

However, much less attention has been paid by medicinal chemists to the field of developing brain targeting drug delivery systems or organ targeting drug delivery systems in a more general perspective via modification of an existing drug delivery system

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Several mechanisms have been proposed to help explain this complex process, including (i) the persistence of HIV viral reservoirs, (ii) the dysregulation of intestinal mucosa and microbial translocation, (iii) the depletion of regulatory T (Treg) cells, and (iv) co-infection with other viruses [13]